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Low vitamin B12 levels can potentiate methotrexate-induced neurotoxicity [149]

CagA prompts carcinogenesis disturbing the activities of tumor suppressor proteins, for example, the run-related transcription factor 3 (RUNX3) and the apoptosis-stimulating protein of p53 2 (ASPP2)

Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways

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While promising, evidence is limited to preclinical data with no registered clinical trials to date, and thus human efficacy and safety remain to be established